学术队伍
基因组与个体_学术队伍1
广西八桂学者-徐剑锋
来源：中心 发布日期：2020-10-27
徐剑锋
博士，教授，硕士/博士生导师
广西八桂学者
美国威克森林大学医学院终身教授
人类基因组中心副主任
肿瘤基因组中心主任
中组部“千人计划”学者
个人简历：博士，教授，硕士/博士生导师
广西八桂学者
美国威克森林大学医学院终身教授
人类基因组中心副主任
肿瘤基因组中心主任
中组部“千人计划”学者
1961年出生，博士，教授。1987年毕业于上海医科大学公共卫生学院，1992年获美国霍普金斯大学预防医学硕士学位，1996年获美国霍普金斯大学公共卫生学院预防医学博士学位。1997-2000年在美国马利兰州大学医学院担任助理教授，并在美国霍普金斯大学公共卫生学院担任兼职助理教授，2000年至今任美国威克森林大学医学院副教授/终身教授，进行遗传流行病学，个体化医学的研究。目前作为首席科学家，担任6个美国国立医学科学院课题。共发表了180篇SCI论文，包括多篇新英格兰医学杂志，自然遗传杂志，科学杂志。2010年作为“千人计划”，引进复旦大学，组建复旦-文安德遗传流行病学研究中心并担任中心主任。
研究方向：
主要从事医学分子遗传学和遗传流行病学研究，利用全基因组关联分析的工具，寻找癌症易感基因，将其研究成果转化为临床应用，包括：疾病诊断、筛选和预防。
主要论著：
1. Wu H, Qian J, Xu J, Sun A, Sun W, Wang Q, Ge J. Besides CYP2C19, PON1 genetic variant influences post-clopidogrel platelet reactivity in Chinese patients. Int J Cardiol. 2013 Apr 30;165(1):204-6.
2. Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth-Little S, Dadaev T, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Campa D, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, Røder MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC; COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative; Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT (Prostate testing for cancer and Treatment) Study Collaborators; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Kote-Jarai Z, Easton DF. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet. 2013 Apr;45(4):385-91.
3. Xu J, Sun J, Zheng SL. Prostate cancer risk-associated genetic markers and their potential clinical utility. Asian J Androl. 2013 May;15(3):314-22.
4. Ding G, Wang L, Xu H, Xu Z, Feng C, Ding Q, Fang Z, Wu Z, Jiang H, Xu J, Gao P. Mesenchymal stem cells in prostate cancer have higher expressions of SDF-1, CXCR4 and VEGF. Gen Physiol Biophys. 2013 Jun;32(2):245-50.
5. Na R, Wu Y, Xu J, Jiang H, Ding Q. Age-specific prostate specific antigen cutoffs for guiding biopsy decision in chinese population. PLoS One. 2013 Jun 25;8(6):e67585. doi: 10.1371/journal.pone.0067585. PMCID: PMC3692456
6. Liu W, Xie CC, Thomas CY, Kim S-T, Lindberg J, Egevad L, Wang Z, Zhang Z, Sun J, Sun J, Koty PP, Kader AK, Cramer SD, Bova GS, Zheng SL, Grönberg H, Isaacs WB, Xu J. Genetic markers associated with early cancer-specific mortality following prostatectomy. Cancer 2013 Jul 1;119(13):2405-12.
7. Han Y, Sun W, Wang L, Tao S, Tian L, Hao Y, Zhang W, Wu S, Li S, Lv H, Zheng SL, Sun J, Xu J. HDAC9 gene is associated with stroke risk in a Chinese population. Exp Biol Med (Maywood). 2013 Jul 1;238(7):842-7.
8. Simonds NI, Khoury MJ, Schully SD, Armstrong K, Cohn WF, Fenstermacher DA, Ginsburg GS, Goddard KA, Knaus WA, Lyman GH, Ramsey SD, Xu J, Freedman AN. Comparative Effectiveness Research in Cancer Genomics and Precision Medicine: Current Landscape and Future Prospects. J Natl Cancer Inst. 2013 Jul 3;105(13):929-36. PMCID: PMC3699435
9. Jiang H, Liu F, Wang Z, Na R, Zhang L, Wu Y, Zheng J, Lin X, Jiang D, Sun J, Zheng SL, Ding Q, Xu J. Prediction of prostate cancer from prostate biopsy in Chinese men using a genetic score derived from 24 prostate cancer risk-associated SNPs. Prostate. 2013 Jul 18. doi: 10.1002/pros.22661. [Epub ahead of print]
10. Qi J, Tian L, Chen Z, Wang L, Tao S, Gu X, Na R, Jiao Y, Kang J, Zheng S, Xu J, Sun J. Genetic Variants in 2q31 and 5p15 Are Associated With Aggressive Benign Prostatic Hyperplasia in a Chinese Population. Prostate. 2013 Aug;73(11):1182-90.
11. Gu X, Huang T, Xu D, Duan L, Jiao Y, Kang J, Zheng SL, Xu J, Sun J, Qi J. Association of a common variant at 10q26 and benign prostatic hyperplasia aggressiveness in han chinese descent. Biochem Res Int. 2013;2013:820849. doi: 10.1155/2013/820849. Epub 2013 Aug 1.
12. Liu W, Wang L, Xu J. Somatic DNA copy number alterations and their potential clinical utility for predicting lethal prostate cancer. Asian J Androl. 2013 Sep;15(5):586-7.
13. Chen Z, Tao S, Gao Y, Zhang J, Hu Y, Mo L, Kim ST, Yang X, Tan A, Zhang H, Qin X, Li L, Wu Y, Zhang S, Zheng SL, Xu J, Mo Z, Sun J. Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men. J Med Genet. 2013 Dec;50(12):794-801. doi: 10.1136/jmedgenet-2013-101705.
14. Wang W, Xu J, Adams TS, Tian Y, Lv W. Pure retroperitoneal laparoscopic radical nephrectomy for left renal cell carcinoma with differential extensions of level I renal vein tumor thrombus. J Endourol. 2013 Oct 7. [Epub ahead of print]
15. Teerlink CC, Thibodeau SN, McDonnell SK, Schaid DJ, Rinckleb A, Maier C, Vogel W, Cancel-Tassin G, Egrot C, Cussenot O, Foulkes WD, Giles GG, Hopper JL, Severi G, Eeles R, Easton D, Kote-Jarai Z, Guy M, Cooney KA, Ray AM, Zuhlke KA, Lange EM, Fitzgerald LM, Stanford JL, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Isaacs WB, Wahlfors T, Tammela T, Schleutker J, Wiklund F, Grönberg H, Emanuelsson M, Carpten J, Bailey-Wilson J, Whittemore AS, Oakley-Girvan I, Hsieh CL, Catalona WJ, Zheng SL, Jin G, Lu L, Xu J; International Consortium for Prostate Cancer Genetics, Camp NJ, Cannon-Albright LA. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease. Hum Genet. 2013 Oct 26. [Epub ahead of print]
16. Chen Y, Li T, Yu X, Xu J, Li J, Luo D, Mo Z, Hu Y. The RTK/ERK pathway is associated with prostate cancer risk on the SNP level: A pooled analysis of 41 sets of data from case-control studies. Gene. 2013 Oct 29. doi:pii: S0378-1119(13)01451-0. 10.1016/j.gene.2013.10.042. [Epub ahead of print]
17. Na R, Liu F, Zhang P, Ye D, Xu C, Shao Q, Qi Q, Wang X, Chen Z, Wang M, He D, Wang Z, Zhou F, Yuan J, Gao X, Wei Q, Yang J, Jiao J, Ou-Yang J, Zhu Y, Wu Q, Chen H, Lu D, Shi R, Lin X, Jiang J, Wang Z, Jiang D, Sun J, Zheng SL, Ding Q, Mo Z, Sun Y, and Xu J. Evaluation of reported prostate cancer risk-associated SNPs from genome-wide association studies of various racial populations in Chinese men. Prostate. 2013 Nov;73(15):1623-35.
18. Stovall DB, Wan M, Miller LD, Cao P, Maglic D, Zhang Q, Stampfer MR, Liu W, Xu J, Sui G. The Regulation of SOX7 and Its Tumor Suppressive Role in Breast Cancer. Am J Pathol. 2013 Nov;183(5):1645-53.
19. Chen Y, Xin X, Li J, Xu J, Yu X, Li T, Mo Z, Hu Y. RTK/ERK Pathway under Natural Selection Associated with Prostate Cancer. PLoS One. 2013 Nov 4;8(11):e78254. doi: 10.1371/journal.pone.0078254.
20. Ho GY, Wang T, Zheng SL, Tinker LF, Xu J, Rohan TE, Wassertheil-Smoller S, Xue X, Augenlicht LH, Peters U, Phipps AI, Strickler HD, Gunter MJ, Cushman M. Circulating Soluble Cytokine Receptors and Colorectal Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2013 Nov 5. [Epub ahead of print]
21. Pan L, Zhang L, Zhang W, Wu X, Li Y, Yan B, Zhu X, Liu X, Yang C, Xu J, Zhou G, Xu A, Li H, Liu Y. A genome-wide association study identifies polymorphisms in the HLA-DR region associated with non-response to hepatitis B vaccination in Chinese Han populations. Hum Mol Genet. 2013 Nov 28. [Epub ahead of print]
22. Ren S*, Xu J*, Zhou T*, Jiang H, Chen H, Liu F, Na R, Zhang L, Wu Y, Sun J, Yang B, Gao X , Zheng SL, Xu C, Ding Q, Sun Y. Plateau effect of prostate cancer risk-associated SNPs in discriminating prostate biopsy outcomes. Prostate. 2013 Dec;73(16):1824-35.
23. Wang P, Ye D, Guo J, Liu F, Jiang H, Gong J, Gu C, Shao Q, Sun J, Zheng SL, Yu H, Lin X, Xia G, Fang Z, Zhu Y, Ding Q, Xu J. Genetic score of multiple risk-associated single nucleotide polymorphisms is a marker for genetic susceptibility to bladder cancer. Genes Chromosomes Cancer. 2014 Jan;53(1):98-105.
24. Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J, Wei GH. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. Nat Genet. 2014 Jan 5. doi: 10.1038/ng.2862. [Epub ahead of print]
25. Saunders EJ, Dadaev T, Leongamornlert DA, Jugurnauth-Little S, Tymrakiewicz M, Wiklund F, Al Olama AA, Benlloch S, Neal DE, Hamdy FC, Donovan JL, Giles GG, Severi G, Gronberg H, Aly M, Haiman CA, Schumacher F, Henderson BE, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock S, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Nordestgaard BG, Canzian F, Campa D, Riboli E, Key TJ, Travis RC, Ingles SA, John EM, Hayes RB, Pharoah P, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park JY, Kaneva R, Batra J, Clements JA, Teixeira MR, Xu J, Mikropoulos C, Goh C, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A; COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative; UK Genetic Prostate Cancer Study Collaborators; UK ProtecT Study Collaborators; PRACTICAL Consortium, Easton DF, Muir K, Eeles RA, Kote-Jarai Z. Fine-Mapping the HOXB Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer. PLoS Genet. 2014 Feb 13;10(2):e1004129
26. Zhou L, He M, Mo Z, Wu C, Yang H, Yu D, Yang X, Zhang X, Wang Y, Sun J, Gao Y, Tan A, He Y, Zhang H, Qin X, Zhu J, Li H, Lin X, Zhu J, Min X, Lang M, Li D, Zhai K, Chang J, Tan W, Yuan J, Chen W, Wang Y, Wei S, Miao X, Wang F, Fang W, Liang Y, Deng Q, Dai X, Lin D, Huang S, Guo H, Lilly Zheng S, Xu J, Lin D, Hu FB, Wu T. A genome wide association study identifies common variants associated with lipid levels in the Chinese population. PLoS One. 2013 Dec 30;8(12):e82420. doi: 10.1371/journal.pone.0082420. eCollection 2013
27. Xu J. The Xu's chart for prostate biopsy: a visual presentation of the added value of biomarkers to prostate-specific antigen for estimating detection rates of prostate cancer. AJA 2014 DOI:10.4103/1008-682X.125907
28. Xiong Z, Yu H, Ding Y, Feng C, Wei H, Tao S, Huang D, Zheng SL, Sun J, Xu J, and Fang Z. RNA Sequencing Reveals Upregulation of RUNX1-RUNX1T1 Gene Signatures in Clear Cell Renal Cell Carcinoma. BioMed Research International 2014 (in press)
